RNA uridylyltransferase
| RNA uridylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.7.52 | ||||||||
| CAS no. | 78519-53-6 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a RNA uridylyltransferase (EC 2.7.7.52) is an enzyme that catalyzes the chemical reaction
- UTP + RNAn diphosphate + RNAn+1
Thus, the two substrates of this enzyme are UTP and RNAn, whereas its two products are diphosphate and RNAn+1.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:RNA uridylyltransferase. Other names in common use include terminal uridylyltransferase, and TUT.
Structural studies
[edit]As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB: 2E5G, PDB: 2IKF, PDB: 2NOM, PDB: 2Q0C, PDB: 2Q0D, PDB: 2Q0E, PDB: 2Q0F, and PDB: 2Q0G.
References
[edit]- Zabel P, Dorssers L, Wernars K, Van Kammen A (June 1981). "Terminal uridylyl transferase of Vigna unguiculata: purification and characterization of an enzyme catalyzing the addition of a single UMP residue to the 3'-end of an RNA primer". Nucleic Acids Research. 9 (11): 2433–53. doi:10.1093/nar/9.11.2433. PMC 326863. PMID 6269049.
 | This EC 2.7 enzyme-related article is a stub. You can help Wikipedia by adding missing information. |