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Quercetin-3,3'-bissulfate 7-sulfotransferase

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Quercetin-3,3'-bissulfate 7-sulfotransferase
Identifiers
EC no.2.8.2.28
CAS no.121855-13-8
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Quercetin-3,3'-bissulfate 7-sulfotransferase (EC 2.8.2.28) is an enzyme that catalyzes the chemical reaction

+ PAPS
 
 
 
 
Rightward reaction arrow
 
 
 
+ adenosine 3',5'-
bisphosphate
 

It uses the cofactor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to transfer a sulfate group and gives adenosine 3',5'-bisphosphate as a byproduct. The enzyme characterised from Flaveria chlorifolia converts quercetin 3,3'-bissulfate to quercetin 3,3',7-trisulfate. This is part of a sequence of similar reactions which sequentially add sulfate groups to quercetin.[1]

This enzyme is a transferase, specifically a sulfotransferase, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase. Other names in common use include flavonol 7-sulfotransferase, 7-sulfotransferase, and PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase.[2]

References

[edit]
  1. Varin L, Ibrahim RK (July 1989). "Partial Purification and Characterization of Three Flavonol-Specific Sulfotransferases from Flaveria chlorifolia". Plant Physiology. 90 (3): 977–81. doi:10.1104/pp.90.3.977. PMC 1061831. PMID 16666908.
  2. Enzyme 2.8.2.28 at KEGG Pathway Database.