Pseudobaptigenin synthase
| Pseudobaptigenin synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.19.63 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pseudobaptigenin synthase (EC 1.14.19.63) is an enzyme with systematic name calycosin,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming).[1] This enzyme catalyses two related chemical reactions:[2]
Pseudobaptigenin synthase is a cytochrome P450 protein containing heme. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate (NADPH).[2] Pratensein, a derivative of calycosin with an extra hydroxy group, is similarly converted into 5-hydroxypseudobaptigenin:[1]
The enzyme isolated from chickpea is part of the biosynthetic pathway to pterocarpans which act as phytoalexins.[1][3]
References
[edit]- 1 2 3 Clemens S, Barz W (1996). "Cytochrome P450-dependent methylenedioxy bridge formation in Cicer arietinum". Phytochemistry. 41 (2): 457–460. Bibcode:1996PChem..41..457C. doi:10.1016/0031-9422(95)00618-4.
- 1 2 Enzyme 1.14.19.63 at KEGG Pathway Database.
- ↑ Hinderer W, Flentje U, Barz W (1987). "Microsomal isoflavone 2'-hydroxylases and 3'-hydroxylases from chickpea (Cicer arietinum L) cell-suspensions induced for pterocarpan phytoalexin formation". FEBS Lett. 214: 101–106. doi:10.1016/0014-5793(87)80021-2.
External links
[edit]- Pseudobaptigenin+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
