Interface hepatitis
Interface hepatitis, formerly known as piecemeal necrosis, nibbling necrosis,[1] and interface necrosis,[1] describes the death of liver cells (hepatocytes) at the lobular-portal-interface, which occurs cell-by-cell (hence "piecemeal"), producing an irregular appearance.[2] Since the underlying mechanism of liver cell death is apoptosis and not necrosis, the term "interface hepatitis" is considered less misleading.[2]
Interface hepatitis is characterized by infiltration of lymphocytes[3] into the adjacent parenchyma,[4] and with destruction of individual hepatocytes along the edges of the portal tract.[4] It has been found to occur in chronic hepatitis, particularly in the chronic forms of viral hepatitis, autoimmune hepatitis, and drug-induced liver injury.[1]
References
[edit]- 1 2 3 Wang, M.; Morgan, T.; Lungo, W.; Wang, L.; Sze, G. Z.; French, S. W. (2001). ""Piecemeal" Necrosis: Renamed Troxis Necrosis". Experimental and Molecular Pathology. 71 (2): 137–146. doi:10.1006/exmp.2001.2397. PMID 11599920.
- 1 2 Rosai, Juan; Ackerman, Lauren V. (June 20, 2011). Rosai and Ackerman's Surgical Pathology (10th ed.). Edinburgh: Mosby. p. 865. ISBN 9780323088046.
- ↑ Pathbase > MPATH 597: cell and tissue damage process > MPATH 13: piecemeal necrosis Retrieved July 2, 2011
- 1 2 Transplant Pathology at the University of Pittsburgh > Chronic hepatitis > Chapter 3 > PATHOLOGIC FEATURES Last Modified: Mar 12, 2010
