Darwin Tree of Life
| Darwin Tree of Life | |
|---|---|
| Project type | Scientific research |
| Funding agency | Wellcome Trust |
| Objective | Genome sequencing of eukaryotes |
| Location | UK, Ireland |
| Project coordinator | Mark Blaxter |
| Participants | |
| Duration | 1 November 2018 – 2028 |
| Website | www |
The Darwin Tree of Life (DToL) is a scientific research project established to sequence the genomes of all eukaryotes in Britain and Ireland. Launched in 2018, the project is led by the Wellcome Sanger Institute and funded by the Wellcome Trust.[1][2] It is a collaboration of universities, museums, and research institutes to produce high-quality genome sequences that are accessible to everyone and will be useful for understanding biodiversity, agricultural values and diseases.[3] It is part of the global Earth BioGenome Project that aims to sequence and catalog the genomes of all eukaryotes on Earth.[4][5]
Background
[edit]In 1837, Charles Darwin made a branching line diagram which he labelled "I think" as a hypothesis of species relationship.[6][7] In his Origin of Species (1859), he made another line drawing for an evolutionary network and common ancestry of different species that he called the "Tree of Life."[8] In 1866, Ernst Haeckel made a literal tree diagram in his book Generalle Morphologie ("General Morphology") depicting evolution of life from bacteria (he called moneres) to different branches of protists, plants and animals.[9] As evidence and understanding of evolutionary theories grew, the concept of the tree of life became a major goal of modern biology.[10][11] With the development of genome sequencing methods in the 21st century, it became possible to construct the actual patterns of the tree of life.[12][13]
By 2018, about 1.5 million species of eukaryotes have been recorded that include protists, plants, fungi and animals.[4] The genomes of many eukaryotic species had been fully sequenced ranging from the roundworm, Caenorhabditis elegans, the first multicellular organism to be sequenced in 1998,[14] malarial parasite, Plasmodium falciparum, the first protist sequenced in 2002,[15] to humans with the sequencing completed in 2022.[16] Depending on the quality and completeness of the sequence, and the number of species added to the completion record, the eukaryotic tree of life kept on changing in the branching details, and thus, a comprehensive data and species are required for an accurate picture.[17][18]
The project
[edit]The Darwin Tree of Life was launched in London, England, on 1 November 2018, as part of the global Earth BioGenome Project that plans to sequence all eukaryotic genomes.[19] The Darwin Tree of Life will target eukaryotic species documented in UK and Ireland, about 70,000 species.[3] The project is led by Mark Blaxter at the Wellcome Sanger Institute,[20] and the European Bioinformatics Institute will be responsible for recording the genome sequences and make them accessible.[19] In addition to the two organisations, participating institutions include:[21]
- Earlham Institute
- Marine Biological Association
- Natural History Museum, London
- Royal Botanic Gardens, Kew
- Royal Botanic Garden Edinburgh
- University of Cambridge
- University of Edinburgh
- University of Oxford
The project is funded by the Wellcome Trust, a charitable foundation based in London, with the initial budget of £100 million with the total of £600 million for completion. The complete sequencing of all the target species is expected by 2028.[19]
Concept
[edit]In 2021, the Darwin Tree of Life Project Consortium explained the concept behind the project in the Proceedings of the National Academy of Sciences with a statement:
The need for understanding [of all species] is critical, as climate change, globalization of trade, and the degradation of agricultural and natural habitats drive the sixth mass extinction, and with it the productivity on which humans depend. The looming need to establish postoil economies and the promise of new feedstocks for bioindustry demand deeper exploration of the biosphere. We need novel medicines to combat emerging and resurgent diseases, and the natural pharmacopoeia has much to offer in the form of novel compounds. Openly accessible understanding of species' biology is a global good.[3]
According to Blaxter and his colleagues, the project will be an accomplishment on Charles Darwin's theory of evolution: "Elucidation of the processes of evolution and speciation since Darwin's The Origin of Species [that] demonstrates the interconnectedness of all life.[22]
References
[edit]- ↑ Brackley, Paul (2018-11-18). "Scientists aim to sequence all 1.5 million known species on Earth - and Wellcome Sanger Institute will play leading role". Cambridge Independent. Retrieved 2026-09-16.
- ↑ "Ambitious project launched to map genomes of all life in British Isles". University of Cambridge. 2019-11-08. Retrieved 2026-09-16.
- 1 2 3 The Darwin Tree of Life Project Consortium (2022-01-25). "Sequence locally, think globally: The Darwin Tree of Life Project". Proceedings of the National Academy of Sciences. 119 (4) e2115642118. Bibcode:2022PNAS..11915642D. doi:10.1073/pnas.2115642118. PMC 8797607. PMID 35042805.
- 1 2 "Life on Earth to have its DNA analysed in the name of conservation". Nature. 563 (7730): 155–156. November 2018. Bibcode:2018Natur.563..155.. doi:10.1038/d41586-018-07323-y. PMID 30401859.
- ↑ Lawniczak, Mara K.N.; Davey, Robert P.; Rajan, Jeena; Pereira-da-Conceicoa, Lyndall L.; Kilias, Estelle; Hollingsworth, Peter M.; Barnes, Ian; Allen, Heather; et al. (2022-07-12). "Specimen and sample metadata standards for biodiversity genomics: a proposal from the Darwin Tree of Life project". Wellcome Open Research. 7: 187. doi:10.12688/wellcomeopenres.17605.1. ISSN 2398-502X. S2CID 250509570.
- ↑ Gontier, Nathalie (2011-09-01). "Depicting the Tree of Life: the Philosophical and Historical Roots of Evolutionary Tree Diagrams". Evolution: Education and Outreach. 4 (3): 515–538. doi:10.1007/s12052-011-0355-0. ISSN 1936-6434.
- ↑ Hellström, Nils Petter (2012). "Darwin and the Tree of Life: the roots of the evolutionary tree". Archives of Natural History. 39 (2): 234–252. doi:10.3366/anh.2012.0092. ISSN 0260-9541.
- ↑ Doolittle, W. Ford; Bapteste, Eric (2007-02-13). "Pattern pluralism and the Tree of Life hypothesis". Proceedings of the National Academy of Sciences. 104 (7): 2043–2049. doi:10.1073/pnas.0610699104. PMC 1892968. PMID 17261804.
- ↑ Kutschera, U. (2016-07-26). "Haeckel's 1866 tree of life and the origin of eukaryotes". Nature Microbiology. 1 (8) 16114. doi:10.1038/nmicrobiol.2016.114. ISSN 2058-5276. PMID 27573115.
- ↑ Doolittle, W. Ford (2000). "Uprooting the Tree of Life". Scientific American. 282 (2): 90–95. Bibcode:2000SciAm.282b..90D. doi:10.1038/scientificamerican0200-90. ISSN 0036-8733. JSTOR 26058605. PMID 10710791.
- ↑ Koonin, Eugene V.; Wolf, Yuri I. (2009-09-29). "The fundamental units, processes and patterns of evolution, and the Tree of Life conundrum". Biology Direct. 4 (1): 33. doi:10.1186/1745-6150-4-33. ISSN 1745-6150. PMC 2761301. PMID 19788730.
- ↑ Delsuc, Frédéric; Brinkmann, Henner; Philippe, Hervé (2005). "Phylogenomics and the reconstruction of the tree of life". Nature Reviews Genetics. 6 (5). Nature Publishing Group: 361–375. doi:10.1038/nrg1603. ISSN 1471-0064. PMID 15861208.
- ↑ Hug, Laura A.; Baker, Brett J.; Anantharaman, Karthik; Brown, Christopher T.; Probst, Alexander J.; Castelle, Cindy J.; Butterfield, Cristina N.; Hernsdorf, Alex W.; et al. (2016-04-11). "A new view of the tree of life". Nature Microbiology. 1 (5): 16048. doi:10.1038/nmicrobiol.2016.48. ISSN 2058-5276. PMID 27572647.
- ↑ Blaxter, Mark (2003). "Two worms are better than one". Nature. 426 (6965): 395–396. doi:10.1038/426395a. ISSN 1476-4687. PMID 14647365.
- ↑ Schoenle, Alexandra; Francis, Ore; Archibald, John M.; Burki, Fabien; Vries, Jan de; Dumack, Kenneth; Eme, Laura; Florent, Isabelle; et al. (2025-10-01). "Protist genomics: key to understanding eukaryotic evolution". Trends in Genetics. 41 (10): 868–882. doi:10.1016/j.tig.2025.05.004. ISSN 0168-9525. PMID 40517085.
- ↑ Lovell, John T.; Grimwood, Jane (2022-06-16). "The first complete human genome". Nature. 606 (7914): 468–469. Bibcode:2022Natur.606..468L. doi:10.1038/d41586-022-01368-w. ISSN 0028-0836. PMID 35606432.
- ↑ Sibbald, Shannon J.; Archibald, John M. (2017-04-20). "More protist genomes needed". Nature Ecology & Evolution. 1 (5). Nature Publishing Group: 0145. Bibcode:2017NatEE...1..145S. doi:10.1038/s41559-017-0145. ISSN 2397-334X. PMID 28812681.
- ↑ Keeling, Patrick J.; Burki, Fabien (2019-08-19). "Progress towards the Tree of Eukaryotes". Current Biology. 29 (16): R808–R817. Bibcode:2019CBio...29.R808K. doi:10.1016/j.cub.2019.07.031. ISSN 0960-9822. PMID 31430481.
- 1 2 3 European Bioinformatics Institute (2018-11-01). "Genomes of all known UK species to be sequenced". www.ebi.ac.uk. Retrieved 2026-09-17.
- ↑ Sample, Ian (2025-04-03). "Top genome scientists to map DNA sequence of invertebrate winner 2025". The Guardian. ISSN 0261-3077. Retrieved 2026-09-17.
- ↑ "Ambitious project launched to map genomes of all life in British Isles". University of Cambridge. 2019-11-08. Retrieved 2026-09-17.
- ↑ Blaxter, Mark; Archibald, John M.; Childers, Anna K.; Coddington, Jonathan A.; Crandall, Keith A.; Di Palma, Federica; Durbin, Richard; Edwards, Scott V.; et al. (2022-01-25). "Why sequence all eukaryotes?". Proceedings of the National Academy of Sciences. 119 (4) e2115636118. Bibcode:2022PNAS..11915636B. doi:10.1073/pnas.2115636118. PMC 8795522. PMID 35042801.