ACDC domain
| AP2-Coincident Domain mainly at the Carboxy-terminus domain | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ACDC | ||||||
| Pfam | PF14733 | ||||||
| |||||||
The AP2-Coincident Domain mainly at the Carboxy-terminus, or ACDC domain, is a protein domain that occurs in proteins from apicomplexan parasites.[1] The function of this domain is unknown. The ACDC domain contains a unique noncanonical four-helix bundle. Biochemical studies of various anti-malarial compounds found five lead-based compounds bound to the hydrophobic pocket formed by the four-helix bundle, implicating this domain as a potential target for future treatments.[2]
The ACDC domain is found exclusively in apicomplexan proteins that also contain AP2 (Apetala 2-integrase) DNA binding domains (ApiAP2 proteins).[3] In 8 of 9 known examples in the malarial parasite Plasmodium falciparum, the domain is located near the carboxy terminus, with the last example having it located at the amino terminus. Two proteins with the ACDC domain were found in the nucleus of P. falciparum, as detected by a proteomic method, suggesting a role in nuclear biology.[1]
References
[edit]- 1 2 Oehring SC, Woodcroft BJ, Moes S, Wetzel J, Dietz O, Pulfer A, Dekiwadia C, Maeser P, Flueck C, Witmer K, Brancucci NM, Niederwieser I, Jenoe P, Ralph SA, Voss TS (November 2012). "Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum". Genome Biology. 13 (11) R108. doi:10.1186/gb-2012-13-11-r108. PMC 4053738. PMID 23181666.
- ↑ Le Berre, Marine; Tubiana, Thibault; Reuterswärd Waldner, Philippa; Lazar, Noureddine; Li de la Sierra-Gallay, Ines; Santos, Joana M.; Llinás, Manuel; Nessler, Sylvie (2025-01-01). "Structural characterization of the ACDC domain from ApiAP2 proteins, a potential molecular target against apicomplexan parasites". Acta Crystallographica Section D. 81 (Pt 1): 38–48. Bibcode:2025AcCrD..81...38L. doi:10.1107/S2059798324012518. ISSN 2059-7983. PMC 11740583. PMID 39820027.
- ↑ Jeninga, Myriam D.; Quinn, Jennifer E.; Petter, Michaela (2019-04-07). "ApiAP2 Transcription Factors in Apicomplexan Parasites". Pathogens (Basel, Switzerland). 8 (2): 47. doi:10.3390/pathogens8020047. ISSN 2076-0817. PMC 6631176. PMID 30959972.