AAR2

AAR2
Identifiers
Aliases	AAR2, C20orf4, CGI-23, AAR2 splicing factor homolog, AAR2 splicing factor
External IDs	OMIM: 617365; MGI: 1915545; GeneCards: AAR2
Gene location (Human)
Chr.	Chromosome 20 (human)
End	36,270,918 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	156,410,892 bp
RNA expression pattern
	Top expressed in
	smooth muscle tissue; ; popliteal artery; ; tibial arteries; ; gonad; ; muscle layer of sigmoid colon; ; right adrenal cortex; ; right coronary artery; ; pancreatic ductal cell; ; islet of Langerhans; ; left coronary artery;
	Top expressed in
	spermatocyte; ; interventricular septum; ; lumbar spinal ganglion; ; Paneth cell; ; muscle of thigh; ; Epithelium of choroid plexus; ; right kidney; ; substantia nigra; ; dentate gyrus of hippocampal formation granule cell; ; spermatid;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	25980
	68295
	ENSG00000131043
	ENSMUSG00000027628
	Q9Y312
	Q9D2V5
	NM_001271874; NM_015511
	NM_001164818; NM_026661
	NP_001258803; NP_056326
	NP_001158290; NP_080937
	Wikidata
View/Edit Human	View/Edit Mouse

AAR2 splicing factor is a protein that in humans is encoded by the gene AAR2. This protein is essential for pre-mRNA splicing, a step in post-transcriptional modification of RNA.^[5] The AAR2 protein is part of the U5 small nuclear ribonucleoprotein complex (snRNP), and it plays a role in a component of the spliceosome.^[6] In humans, the AAR2 gene is on chromosme 20.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131043 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027628 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Q9Y312 · AAR2_HUMAN". www.uniprot.org. UniProt. Retrieved 2023-12-14.
↑ Nakazawa, N.; Harashima, S.; Oshima, Y. (November 1991). "AAR2, a gene for splicing pre-mRNA of the MATa1 cistron in cell type control of Saccharomyces cerevisiae". Molecular and Cellular Biology. 11 (11): 5693–5700. doi:10.1128/mcb.11.11.5693-5700.1991. ISSN 0270-7306. PMC 361940. PMID 1922071.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131043 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027628 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Q9Y312 · AAR2_HUMAN". www.uniprot.org. UniProt. Retrieved 2023-12-14.

[6] Nakazawa, N.; Harashima, S.; Oshima, Y. (November 1991). "AAR2, a gene for splicing pre-mRNA of the MATa1 cistron in cell type control of Saccharomyces cerevisiae". Molecular and Cellular Biology. 11 (11): 5693–5700. doi:10.1128/mcb.11.11.5693-5700.1991. ISSN 0270-7306. PMC 361940. PMID 1922071.

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