4-Hydroxygramine
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| Formula | C11H14N2O |
| Molar mass | 190.246 g·mol−1 |
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4-Hydroxygramine is a serotonergic and a serotonin antagonist belonging to the class of indole-3-methanamines, a family of indoles with a single-carbon chain that are related to tryptamines.[1][2]
Pharmacology
[edit]Pharmacodynamics
[edit]4-Hydroxygramine is an antagonist of several subtypes of 5-hydroxytryptamine receptors; it has a high affinity for the 5-HT2C receptor, with an affinity (Ki) of 24 ± 0.8 nM, followed by binding to the 5-HT2A and 5-HT2B receptors (with Ki values of 923 ± 224 and 1242 ± 295, respectively).[2]
See also
[edit]References
[edit]- ↑ Troxler F, Seemann F, Hofmann A (1959). "Abwandlungsprodukte von psilocybin und psilocin. 2. Mitteilung über synthetische indolverbindungen" [Synthetic indole compounds. II. Psilocybin and psilocin modifications]. Helvetica Chimica Acta (in German). 42 (6): 2073–2103. doi:10.1002/hlca.19590420638.
- 1 2 Sard H, Kumaran G, Morency C, Roth BL, Toth BA, He P, et al. (October 2005). "SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist". Bioorganic & Medicinal Chemistry Letters. 15 (20): 4555–4559. doi:10.1016/j.bmcl.2005.06.104. PMID 16061378.