3-oxoacyl-(acyl-carrier-protein) reductase
| 3-oxoacyl-[acyl-carrier-protein] reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 3-oxoacyl-[acyl-carrier-protein] reductase homotetramer, Vibrio cholerae | |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.1.100 | ||||||||
| CAS no. | 37250-34-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) is an enzyme that catalyzes the chemical reaction
- 3-oxoacyl-[acyl-carrier-protein](ACP) + NADPH + H+ (3R)-3-hydroxyacyl-[acyl-carrier-protein](ACP) + NADP+
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group as hydride donor with NAD+ or NADP+ as hydride acceptor. The systematic name of this enzyme class is (3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP+ oxidoreductase. Other names in common use include beta-ketoacyl-[acyl-carrier protein](ACP) reductase, beta-ketoacyl acyl carrier protein (ACP) reductase, beta-ketoacyl reductase, beta-ketoacyl thioester reductase, beta-ketoacyl-ACP reductase, beta-ketoacyl-acyl carrier protein reductase, 3-ketoacyl acyl carrier protein reductase, 3-ketoacyl ACP reductase, NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase, and 3-oxoacyl-[ACP]reductase. This enzyme participates in fatty acid biosynthesis and polyunsaturated fatty acid biosynthesis.
Structural studies
[edit]As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1I01, PDB: 1O5I, PDB: 1Q7B, PDB: 1Q7C, PDB: 1ULS, PDB: 1UZL, PDB: 1UZM, PDB: 1UZN, PDB: 2A4K, PDB: 2B4Q, PDB: 2C07, PDB: 2FR0, PDB: 2FR1, PDB: 2NM0, PDB: 2NTN, PDB: 2P68, PDB: 2PFF, PDB: 2PH3, PDB: 2PNF, PDB: 2UVD, and PDB: 2Z5L.
References
[edit]- Prescott DJ, Vagelos PR (1972). "Acyl Carrier Protein". Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology - and Related Areas of Molecular Biology. Vol. 36. pp. 269–311. doi:10.1002/9780470122815.ch8. ISBN 9780470122815. PMID 4561013.
- Shimakata T, Stumpf PK (1982). "Purification and characterizations of beta-Ketoacyl-[acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase from Spinacia oleracea leaves". Arch. Biochem. Biophys. 218 (1): 77–91. doi:10.1016/0003-9861(82)90323-X. PMID 6756317.
- Toomey RE, Wakil SJ (1966). "Studies on the mechanism of fatty acid synthesis. XV. Preparation and general properties of beta-ketoacyl acyl carrier protein reductase from Escherichia coli". Biochim. Biophys. Acta. 116 (2): 189–97. doi:10.1016/0005-2760(66)90001-4. PMID 4381013.
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